Described as the largest educational project in Singapore and Malaya at that time, the Barker Road campus overlooked Bukit Timah and was termed "the Sentinnel of Bukit Timah". This campus would in turn house all the ACS units at one time or another.

With the Barker Road campus up in 1950 and a redevelopment of the Canning Rise site in 1957, all primary classes were moved to Canning Rise. The Junior School moved to Barker Road in the 1980s before being resited at its present location at Peck Hay Road.

The secondary school at Barker Road (now known as Anglo-Chinese School (Independent)) also included the post-secondary section which separated in 1977 to form Anglo-Chinese Junior College.

The secondary school went independent in 1986 and later moved to its present premises in Dover Road in 1991.

In 1994, Anglo-Chinese Primary School moved from Canning Rise to Barker Road and Anglo-Chinese School (Barker Road) was born when a secondary section was added to it.

The school grew rapidly and soon it faced operational and physical constraints as the retrofitted campus had originally been intended for a primary school. It was therefore decided in 1998, to re-develop the campus. The Primary Section of ACS (Barker Road) moved out to its holding school at Ah Hood Road on 15 December 1998 and resumed function as a primary school. The school was renamed Anglo-Chinese School (Primary).

On 4 December 2002, Anglo-Chinese School (Primary) moved back to the Barker Road Campus and began functioning as a single-session primary school. The school was officially opened on 15 July 2003 by DPM Tony Tan.